DIMETHYLNITROSAMINE N DEMETHYLASE Meaning and
Definition
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Dimethylnitrosamine N Demethylase is an enzyme that is involved in the process of detoxifying and degrading dimethylnitrosamine (DMN), a potent carcinogenic compound found in various industrial chemicals, tobacco smoke, and certain food products. The enzyme, also known as DMD or P450 2E1, is primarily found in the liver, specifically in the endoplasmic reticulum of hepatocytes.
The function of dimethylnitrosamine N demethylase is to convert DMN into formaldehyde and dimethylamine, which are less toxic substances. This enzymatic reaction is an important step in the metabolic clearance of DMN from the body. The activity of the enzyme is highly regulated and can be influenced by various factors, including genetic polymorphisms, environmental factors, and exposure to other chemicals.
The significance of dimethylnitrosamine N demethylase lies in its ability to protect the body from the harmful effects of DMN by facilitating its neutralization and elimination. Studies have shown that individuals with lower activity of this enzyme may be more susceptible to the carcinogenic effects of DMN, while higher activity may enhance its detoxification.
Overall, dimethylnitrosamine N demethylase is an essential enzyme involved in the metabolism and detoxification of dimethylnitrosamine. Its activity is important for maintaining the body's defense against potential carcinogens, highlighting its role in human health and disease.
Common Misspellings for DIMETHYLNITROSAMINE N DEMETHYLASE
- simethylnitrosamine n demethylase
- ximethylnitrosamine n demethylase
- cimethylnitrosamine n demethylase
- fimethylnitrosamine n demethylase
- rimethylnitrosamine n demethylase
- eimethylnitrosamine n demethylase
- dumethylnitrosamine n demethylase
- djmethylnitrosamine n demethylase
- dkmethylnitrosamine n demethylase
- domethylnitrosamine n demethylase
- d9methylnitrosamine n demethylase
- d8methylnitrosamine n demethylase
- dinethylnitrosamine n demethylase
- dikethylnitrosamine n demethylase
- dijethylnitrosamine n demethylase
- dimwthylnitrosamine n demethylase
- dimsthylnitrosamine n demethylase
- dimdthylnitrosamine n demethylase
- dimrthylnitrosamine n demethylase
- dim4thylnitrosamine n demethylase
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